Carmustine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥454.00 | 现货 | |
| 10mg | ￥327.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an antitumor chemotherapeutic agent[1].
In rat glial tumor cytosol and intact cells, carmustine (8, 80, and 800 µM) reduces N-acetyltransferase activities for 2-aminofluorene and p-aminobenzoic acid. In rat glioma cells, carmustine reduces the formation of DNA-AF adducts[1].
Intraperitoneal administration of carmustine 25 mg/kg in rat, which increases liver-to-weight ratio, significantly reduces bile flow, and decreases GSSG and GSH/GSSG values, and mild fibrous edema and monocyte infiltration in the liver of rats[2].
References:
[1].Hung C F. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res, 2000, 25(6): 845-51.
[2].Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res, 2001, 20(1): 133-143.
产品性质
| 物理外观 | A solid |
| CAS号 | 154-93-8 |
| 分子式 | C5H9Cl2N3O2 |
| 分子量 | 214.05 |
| 小分子别名 | Carmustine (Standard) |
| 化学名称 | (Z)-N,N'-bis(2-chloroethyl)-N-nitrosocarbamimidic acid |
| 溶解度 | insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH |
| SMILES | O=C(NCCCl)N(CCCl)N=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 卡莫司汀是一种抗肿瘤化疗药，通过使 DNA 和 RNA 阿克化来发挥作用。 |
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