Catalog No. B7358

BzATP (ammonium salt)

P2X7受体激动剂

规格	价格	货期	数量
1mg	￥866.00	10-15工作日发货

CAS号：112898-15-4纯度：98.00%

仅用于科研，不用于诊疗。未经明确授权不得转售。

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Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

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高效的Cy5修饰RNA转录试剂盒

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产品描述产品性质产品应用生物相关数据质量控制操作说明产品引用文献摩尔浓度计算器

产品描述

BzATP (ammonium salt) is an agonist of the P2X receptors, exhibiting 5-30-fold higher potency at the P2X7 receptor than ATP. BzATP (ammonium salt) inhibits rat and mouse P2X7 receptors with EC50 values being 3.6 and 285 μM, respectively. However, BzATP (ammonium salt) is not selective for the P2X7 receptor as it can potently activate other P2X receptors, but without the marked superiority to ATP as an agonist. Activation of P2X7 receptors contributes to the proliferation and migration of certain types of tumor, including human glioma, and is involved in sepsis-induced intestinal barrier dysfunction. In addition, BzATP (ammonium salt) can also be used as a photoaffinity probe for exploring adenine nucleotide binding to ATPases.

References:

1. Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends in Neurosciences, 2006, 29(5): 257-262.

2. Young MT, Pelegrin P, Surprenant A. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology, 2007, 71(1): 92-100.

3. Ji Z, Xie Y, Guan Y, et al. Involvement of P2X7 receptor in proliferation and migration of human glioma cells. BioMed Research International, 2018, 2018: 8591397.

4. Wu X, Ren J, Chen G, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Scientific Reports, 2017, 7(1): 4364.

5. Williams N, Coleman PS. Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. Journal of Biological Chemistry, 1982, 257(6): 2834-2841.

产品性质

物理外观	A white to off-white solid
CAS号	112898-15-4
分子式	C₃₀H₃₉N₆O₁₅P₃
分子量	816.59
化学名称	triethylamine rac-((2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-3-((4-benzoylbenzoyl)oxy)-4-hydroxytetrahydrofuran-2-yl)methyl triphosphate
溶解度	≤14 mg/ml in DMSO
SMILES	O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O.CCN(CC)CC
存储条件	-20°C
运输条件	蓝冰

产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)

IC50和靶点

生物活性描述

BzATP 三乙基铵盐是一种 P2X7 受体激动剂。

生物相关数据

质量控制

请选择批次查看:

纯度 ≥95.00%

COA (Certificate Of Analysis)MSDS (Material Safety Data Sheet)

操作说明

小分子化合物通用使用指南

APExBIO 顾客使用本产品发表的 2 篇科研文献

1. Ning Liu, Guo-Xin Zhang, et al. "Antinociceptive and neuroprotective effect of echinacoside on peripheral neuropathic pain in mice through inhibiting P2X7R/FKN/CX3CR1 pathway." Biomed Pharmacother. 2023 Dec:168:115675. PMID: 37812887
2. Yu Y, Feng S, et al. "Extracellular ATP activates P2X7R-NF-κB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice." Cytokine. 2019 Jul;119:175-181. PMID:30952064

摩尔浓度计算器

质量

= 浓度

x 体积

x 分子量

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