Bradykinin (acetate)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 10mg | ￥531.00 | 10-15工作日发货 | |
| 25mg | ￥1110.00 | 10-15工作日发货 | |
| 50mg | ￥1630.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].
Bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. It also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. Bradykinin is an inflammatory mediator. The Bradykinin B1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. The Bradykinin B2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.
In cultured endothelial cells, bradykinin promoted a rapid dissociation of the eNOS:B2 receptor complex [2]. In the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with B2 receptors and stimulating tachykinin release from sensory nerves [3].
In healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-PGF1a , the stable hydrolysis product of prostacyclin (PGI2). So bradykinin may have a use as a probe of PG12 production in vivo in pathological states [1].
References:
[1]. Barrow SE, Dollery CT, Heavey DJ, et al. Effect of vasoactive peptides on prostacyclin synthesis in man. Br J Pharmacol. 1986 Jan;87(1):243-7.
[2]. Ju H, Venema VJ, Marrero MB, et al. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase. J Biol Chem. 1998 Sep 11;273(37):24025-9.
[3]. Figini M, Emanueli C, Grady EF, et al. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol. 1997 Apr;272(4 Pt 1):G785-93.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 6846-03-3 |
| 分子式 | C50H73N15O11·XC2H4O2 |
| 分子量 | 1120.3 |
| 化学名称 | (S)-2-((S)-2-((S)-1-((S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-guanidinopentanoic a |
| 溶解度 | ≥113 mg/mL in DMSO with gentle warming; ≥113.5 mg/mL in EtOH with gentle warming; ≥226.6 mg/mL in H2O |
| SMILES | O=C([C@H](CCC1)N1C([C@@H](N)CCCNC(N)=N)=O)N(CCC2)[C@@H]2C(NCC(N[C@H](C(N[C@@H](CO)C(N(CCC3)[C@@H]3C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O.CC(O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 缓激肽（醋酸酯）是一种由桔皮素-激肽系统产生的活性肽。它是一种炎症介质，也被认为是一种神经介质以及多种血管和肾脏功能的调节剂。它由血液中的卡利克林酶酶生成，是一种强大的血管扩张剂，可引起平滑肌收缩，并可介导炎症。它是一种人体血清代谢物和血管扩张剂。它是缓激肽（2+）的同系物。 |
质量控制
APExBIO 顾客使用本产品发表的 2 篇科研文献
- 1. Jiwei Xu, Jianjie Xu, et al. "Impact of different classification schemes on discrimination of proteins with noise-contaminated spectra using laboratory-measured fluorescence data." Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5:296:122646. PMID: 37003145
- 2. Nan N, Wang Q, et al. "The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior." Oxid Med Cell Longev 2023;2023 PMID: 36647428
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