Akt Inhibitor IV

Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC₅₀= 625 nM) and reduces phosphorylation of Akt at Ser⁴⁷³ and Thr³⁰⁸ in a dose-dependent manner.¹ Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC₅₀ = 520 nM).² It also reduces the growth of cancer cells (IC₅₀ = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).³