Catalog No. A8184

AICAR

Name: AICAR, 阿卡地新, 2627-69-2
Brand: APExBIO
SKU: A8184

（别名：阿卡地新）

一种 AMPK 激活剂

规格	价格	货期	数量

CAS号：2627-69-2纯度：99.61%

仅用于科研，不用于诊疗。未经明确授权不得转售。

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特色产品

Annexin V-FITC/PI Apoptosis Kit

用于双染检测细胞凋亡和坏死

- 在10-20分钟内完成染色
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞

Phos binding reagent (Phosbind) acrylamide

分离和检测磷酸化/非磷酸化蛋白

- 新型的磷酸盐结合标签和功能分子
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白

Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

- 比MTT，MTS或WST-1更敏感
- 对细胞无毒性
- 步骤更简单，无需有机溶剂

Cy5 TSA Fluorescence System Kit

Cy5荧光标记的酪胺信号放大系统

- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率

EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)

用于观察mRNA运送，定位，翻译

- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰

HotStart™ 2X Green qPCR Master Mix

用于荧光定量目标DNA或cDNA

- 通过热启动机制优化扩增特异性
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单

HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit Plus

高效的Cy5修饰RNA转录试剂盒

- 适合原位/Northernblot杂交实验
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量

产品描述产品性质生物相关数据质量控制操作说明产品引用文献摩尔浓度计算器

产品描述

AICAR（CAS 2627-69-2）是一种能够透过细胞膜的、别构激活AMP激活蛋白激酶（AMPK）的分子。AMPK是一种由两种不同亚基组成的丝氨酸/苏氨酸蛋白激酶，能够调节细胞的能量状态，从而保护细胞免受代谢应激的影响。AMPK通过磷酸化多种代谢酶，激活分解代谢通路（如酮体生成），并抑制合成代谢通路（如蛋白质合成）。AICAR通过激活核心通路AMPK，在能量代谢调节、代谢性疾病治疗以及细胞应激保护等方面展现出广泛的研究价值。

产品性质

产品有效期	12个月
CAS号	2627-69-2
分子式	C₉H₁₄N₄O₅
分子量	258.23
化学名称	5-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide
溶解度	insoluble in EtOH; ≥12.9 mg/mL in DMSO; ≥52.9 mg/mL in H2O
SMILES	OC[C@H]1O[C@@H](N2C=NC(C(N)=O)=C2N)[C@H](O)[C@@H]1O
存储条件	-20°C
运输条件	蓝冰

生物相关数据

质量控制

请选择批次查看:

纯度 = 99.61%

COA HPLC NMR MSDS

操作说明

Datasheet

APExBIO 顾客使用本产品发表的 14 篇科研文献

1. Shuqi Wang, Li Tang, Mengru Hu. "Isoliensinine from Plumula Nelumbinis Attenuates Hepatic Fibrosis in Metabolic Associated Fatty Liver Disease through Regulating Lipid Droplet Metabolism." Journal of Future Foods Available online 6 November 2025

2. Yanru Ren, Kun Wang, Yuanyuan Wu. "Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy." Int J Biol Macromol . 2025 Apr:301:140488. PMID: 39889999

3. Jiahui Lei, Zhenhui Shu, He Zhu. "AMPK regulates M1 macrophage polarization through the JAK2/STAT3 signaling pathway to attenuate airway inflammation in obesity-related asthma." Inflammation. 2025 Feb;48(1):372-392 PMID: 38886294

4. Alexei Vazquez, et al. "Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing." Nat Commun. 2024 Mar 2;15(1):1931 PMID: 38431691

5. Lin Xu, et al. "Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway." Sci Rep. 2024 Feb 29;14(1):5010 PMID: 38424223

6. Yachun Han, Shan Xiong, et al. "Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy." Cell Death Dis. 2021 Oct 30;12(11):1031 PMID: 34718329

7. Mengqiu Yuan, Ronghui Yan, et al. "CARS senses cysteine deprivation to activate AMPK for cell survival." EMBO J. 2021 Nov 2;40(21):e108028 PMID: 34472622

8. Siwei Xia, Zhimin Wang, et al. "Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal." Biochem Pharmacol. 2021 Oct;192:114730 PMID: 34400125

9. Duan Li, XiaoyanWang, et al. "LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA." Cell Death Discov. 2021 May 16;7(1):107 PMID: 33993190

10. Li N, Wang Y, et al. "Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling." Nat Commun. 2019 Sep 25;10(1):4363.nbsp PMID: 31554794

11. Murakami S, Nemazanyy I, et al. "A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas." Dev Cell. 2019 Aug 12. pii: S1534-5807(19)30628-8 PMID: 31447265

12. Wei Q, Zhang B, et al. "Maslinic Acid Inhibits Colon Tumorigenesis by the AMPK-mTOR Signaling Pathway." J Agric Food Chem. 2019 Apr 17;67(15):4259-4272 PMID: 30913881

13. Chen X, Han Y, et al. "Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy." Kidney Int. 2019 Feb 12. pii: S0085-2538(18)30899-8 PMID: 30791996

14. Xu N, Wang Q, et al. "Fenofibrate improves vascular endothelial function and contractility in diabetic mice." Redox Biol. 2018 Oct 1;20:87-97. 2.Wang L, Xie H, et al."rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway." Theranostics. 2017 Aug 15;7(14):3446-3460 PMID: 30296701