3CAI
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
靶点:AKT
IC50: 1 μM
3CAI是有效的和特异性的AKT变构抑制剂,以ATP非竞争性方式直接与AKT1或AKT2结合,1 μM的3CAI抑制60%的AKT1激酶活性[1]。丝氨酸/苏氨酸激酶AKT包括三个成员:AKT1、AKT2和AKT3。AKT通过诱导细胞增殖和抑制细胞凋亡,在促进转化和化学抗性中发挥关键作用。因此,AKT被认为是癌症治疗的潜在靶标。
体外实验:1和4 μM的3CAI显著抑制AKT1激酶活性,降低AKT的直接下游靶标包括mTOR和GSK3β的表达。在HCT116或HCT29结肠癌细胞中,4 μM的3CAI有效诱导生长抑制和细胞凋亡[1]。
体内实验:在体内异种移植小鼠模型中,口服给药30 mg/kg的3CAI显著抑制结肠癌的生长,抑制HCT116结肠肿瘤组织中AKT靶蛋白如mTOR和GSK3β 的表达[1]。
参考文献:
1. Kim DJ, Reddy K, Kim MO, Li Y, Nadas J, Cho YY, et al. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer Prev Res (Phila). 2011;4(11):1842-51.
Storage | Store at -20°C |
M.Wt | 193.63 |
Cas No. | 28755-03-5 |
Formula | C10H8ClNO |
Solubility | insoluble in EtOH; insoluble in H2O; ≥6.8 mg/mL in DMSO |
SDF | Download SDF |
Canonical SMILES | ClCC(C1=CNC2=CC=CC=C21)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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