MAPK Signaling
The mitogen-activated protein kinase (MAPK) is a highly conserved family of serine/threonine kinases that mediate a board range of cellular processes, including proliferation, differentiation, motility, migration, stress response, apoptosis and survival. The activation of MAPK involves signaling pathways consisting of MAPK kinase (i.e. MAPKKK or MEKK) that activates MAPK/ERK (i.e. MAPKK or MEK). A variety of extracellular signals such as mitogens, cytokines, growth factors, and environmental stressors stimulate a phosphorylation-dependent increase in the activity of MAPK.
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
- B5817 GDC-09942 CitationSummary: ERK1/2抑制剂
- B4937 SB 706504Summary: p38 MAPK抑制剂
- B4886 DTP3 TFASummary: GADD45β/MKK7复合体抑制剂
- A9502 OTS964 hydrochlorideSummary: TOPK抑制剂
- A9501 OTS514Summary: TOPK抑制剂
- B7791 6-Bnz-cAMP sodium saltSummary: cAMP类似物,PKA激活剂。
- B7784 AL 8697Target: p38Summary: 有效的p38α选择性抑制剂
- A9907 MEK Inhibitor SetSummary: 用于磷酸化和去磷酸化
- B5727 PD 334581Summary: MEK1抑制剂
- B7748 DBM 1285 dihydrochlorideSummary: p38 MAPK抑制剂