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首页 >> Signaling Pathways >> Proteases >> HIV Protease

HIV Protease

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

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  1. 产品编号 产品名称 信息
  2. A8204 Lopinavir Top Seller HIV蛋白酶抑制剂
  3. A8205 Atazanavir Top Seller HIV蛋白酶抑制剂
  4. B4950 Darunavir Ethanolate 非肽HIV蛋白酶抑制剂
  5. A4040 Atazanavir sulfate (BMS-232632-05) 蛋白酶抑制剂
  6. A8203 Ritonavir Top Seller HIV蛋白酶抑制剂
  7. A8206 Darunavir Top Seller HIV-1蛋白酶抑制剂
  8. A8201 Amprenavir (agenerase) Top Seller HIV-1蛋白酶抑制剂
  9. A3253 BMS-626529 HIV-1吸附的抑制剂
  10. A3421 Fosamprenavir Calcium Salt 抗逆转录病毒蛋白酶抑制剂amprenavir的前药。
  11. A3462 HIV-1 integrase inhibitor 2 HIV-1整合酶抑制剂
  12. A3653 Nelfinavir Mesylate HIV蛋白酶抑制剂,治疗HIV的抗逆转录病毒药物
  13. A3790 Saquinavir HIV蛋白酶抑制剂
  14. A3791 Saquinavir mesylate HIV蛋白酶抑制剂
  15. A3876 Tipranavir HIV蛋白酶抑制剂