EBE-A22
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
EBE-A22是PD153035衍生物，PD153035能抑制ErbB-1磷酸化，但EBE-A22则无此活性。溴化苯胺基喹唑啉衍生物 PD153035对表皮生长因子受体酪氨酸激酶(EGF-RTK)表现出非常高的亲和力和选择性，并对几种类型的肿瘤细胞系显示出显着的细胞毒性。相比之下，其N-甲基衍生物，命名为EBE-A22，对EGF-RTK没有影响，但保持高细胞毒性特征。
参考文献：
[1]. Goossens JF, Bouey-Bencteux E, Houssin R, Hénichart JP, Colson P, Houssier C, Laine W, Baldeyrou B, Bailly C. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71. doi: 10.1021/bi002777a. PMID: 11294633.
| Storage | Store at -20°C |
| M.Wt | 374.24 |
| Cas No. | 229476-53-3 |
| Formula | C17H16BrN3O2 |
| Solubility | ≥37.5 mg/mL in DMSO |
| Chemical Name | N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine |
| SDF | Download SDF |
| Canonical SMILES | BrC1=CC(N(C)C2=NC=NC3=CC(OC)=C(OC)C=C23)=CC=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
