b-Casomorphin (1-3)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
β-酪啡肽(1-3)化学式为C23H27N3O5,是一个三肽序列,序列为H2N-Tyr-Pro-Phe-OH,分子量为425.48。酪啡肽来源于牛奶酪蛋白消化物。酪啡肽的显著特点是它们具有阿片样效果。β-酪啡肽是从β酪蛋白消化成的,是来源于牛奶的最重要的酪啡肽,根据它的氨基酸序列有时将它称为BCM。酪蛋白主要有两种变体:A1和A2。在牛中,A1型的β酪蛋白含有67位的组氨酸,研究表明,BCM7是一种酪啡肽,只能由A2型β酪蛋白释放(1)。每升牛奶释放约0.4g BCM7(假设每升有12 g β酪蛋白)。Dipeptidyl peptidase-4可以将酪啡肽消化分解成无活性的二肽(2),这种酶存在于消化道和一些内分泌细胞。在胃中,酪蛋白可以消化分解产生酪啡肽,作为阿片类药充当组胺释放剂(3)。
Figure1 Formula of b-Casomorphin (1-3)
Figure 2 Caseins exist in large spherical collodial micells with calcium phosphate
参考文献:
1. Jinsmaa Y, Yoshikawa M, 1999; "Enzymatic release of neocasomorphin and beta-casomorphinfrom bovine beta-casein"; Peptides 20:957-962
2. Converse PJ, Hamosh A, McKusickVA(2005). DIPEPTIDYL PEPTIDASE IV; DPP4. Online Mendelian Inheritance inMan.
3. Kurek M, Przybilla B, Hermann K, Ring J (1992). "A naturally occurring opioid peptide from cow's milk, beta-casomorphine-7, is a direct histamine releaser in man". Int Arch Allergy Immunol 97 (2): 115–120.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 425.48 |
Cas No. | 72122-59-9 |
Formula | C23H27N3O5 |
Synonyms | H2N-Tyr-Pro-Phe-OH |
Solubility | ≥13.46 mg/mL in H2O; ≥17.93 mg/mL in EtOH; ≥42.5 mg/mL in DMSO |
Chemical Name | 2-[[1-[2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid |
SDF | Download SDF |
Canonical SMILES | C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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