MAPK Signaling
The mitogen-activated protein kinase (MAPK) is a highly conserved family of serine/threonine kinases that mediate a board range of cellular processes, including proliferation, differentiation, motility, migration, stress response, apoptosis and survival. The activation of MAPK involves signaling pathways consisting of MAPK kinase (i.e. MAPKKK or MEKK) that activates MAPK/ERK (i.e. MAPKK or MEK). A variety of extracellular signals such as mitogens, cytokines, growth factors, and environmental stressors stimulate a phosphorylation-dependent increase in the activity of MAPK.
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
- B7738 SR 35761 CitationTarget: JNKSummary: JNK3抑制剂
- B7450 SX 011Summary: p38α抑制剂
- B7444 SU 3327Summary: JNK抑制剂
- B7321 TCS JNK 6o中文名: JNK抑制剂8Target: JNKSummary: JNK抑制剂
- B7307 L-779,450Summary: Raf激酶抑制剂
- B7276 XRP44XSummary: Ras-Net(Elk-3)通路抑制剂
- B7215 EO 1428Summary: p38α和p38β2抑制剂
- B7140 JX 401Summary: p38α抑制剂
- B6962 CMPD-1Target: Microtubules/Tubulins|MK2Summary: p38α介导的MK2a磷酸化的抑制剂
- B6921 SKF 86002 dihydrochlorideSummary: p38 MAP激酶抑制剂