APExBIO

Catalog No. L1021P

DiscoveryProbe™ FDA-approved Drug Library Plus

3000+个获得上市批准的化合物。

规格	价格	货期	数量
20uL(10mM solution, 96 Well Microplates)	￥28750.00 ￥11500.00	15-20工作日发货
100uL(96 Well Deep Well Plate)	￥64690.00 ￥25876.00	15-20工作日发货
100uL(96 Well Racks With Screw Cap)	￥117890.00	15-20工作日发货
250uL(96 Well Racks With Screw Cap)	￥213380.00	15-20工作日发货

仅用于科研，不用于诊疗。未经明确授权不得转售。

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021-55669583sales@apexbio.cnAPExBIO

特色产品

Annexin V-FITC/PI Apoptosis Kit

用于双染检测细胞凋亡和坏死

- 在10-20分钟内完成染色
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞

Phos binding reagent (Phosbind) acrylamide

分离和检测磷酸化/非磷酸化蛋白

- 新型的磷酸盐结合标签和功能分子
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白

Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

- 比MTT，MTS或WST-1更敏感
- 对细胞无毒性
- 步骤更简单，无需有机溶剂

Cy5 TSA Fluorescence System Kit

Cy5荧光标记的酪胺信号放大系统

- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率

EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)

用于观察mRNA运送，定位，翻译

- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰

HotStart™ 2X Green qPCR Master Mix

用于荧光定量目标DNA或cDNA

- 通过热启动机制优化扩增特异性
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单

HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit Plus

高效的Cy5修饰RNA转录试剂盒

- 适合原位/Northernblot杂交实验
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量

产品描述产品性质操作说明产品引用文献摩尔浓度计算器

产品描述

L1021P 为 DiscoveryProbe™ 批准上市化合物库，是在 L1021M 的基础上进一步扩充而来，共收录 3000+ 种来自 FDA、EMA、HMA、CFDA、PMDA 等全球主要监管机构批准的化合物，其中部分未通过 FDA 批准。这些化合物安全性良好，广泛应用于体外和体内实验研究，非常适合高通量筛选（HTS）与高内涵筛选（HCS），有助于快速发现新的药物作用靶点，是推进药物再开发的有力工具。

产品特点

-- 生物活性强，具备选择性，能够渗透细胞，实现对靶点的有效抑制或激活。

-- 化学结构多样，给药途径丰富（口服/肌肉注射/静脉注射等）。

-- 提供详细的文件资料，包括化合物的效力、选择性及具体应用领域等信息。

-- 拥有广泛且权威的文献支持和客户反馈

-- 经过NMR和HPLC测定，确保化合物纯度

产品性质

产品有效期	12个月
存储条件	-20°C及以下
运输条件	干冰

操作说明

化合物库使用说明小分子化合物通用使用指南

APExBIO 顾客使用本产品发表的 77 篇科研文献

1. Liang Lin, Hao Ke, et al. "Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs." Free Radical Biology and Medicine Volume 250, July 2026, Pages 64-79. PMID: 41862009

2. Rui He, Yanzhen Li, et al. "Cabozantinib inhibits necroptosis by targeting MLKL oligomerization and alleviates psoriasis in vivo." Biochemical Pharmacology Volume 248, June 2026, 117843. PMID: 41747872

3. Shirley Genah, Marsha Pellegrino, et al. "Proteasome inhibition promotes Foxn1 expression in thymic epithelial cells and induces thymic regeneration in mice." Cell Death Differ. 2026 Mar 26

4. Dominik Macak, Philipp Kanis, et al. "Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality." Nat Commun. 2025 Dec 10;16(1):11077. PMID: 41372233

5. Alejo Antonio Morales, Vladimir Camarena, et al. "Glucocorticoid treatment rescues early lethality in a mouse model of geleophysic dysplasia." Commun Biol. 2025 Nov 26;8(1):1707. PMID: 41298911

6. Cheng Yu, Jinyu Liu, et al. "ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells." Cell Death Discov. 2025 Nov 17;11(1):532. PMID: 41249117

7. Siyi He, Daniel Meister, et al. "A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins." Cell Death Dis. 2025 Nov 10;16(1):825. PMID: 41213973

8. Sien Lequeue, Hind Allach, et al. "A robust bacterial high-throughput screening assay to identify pharmacological chaperones targeting human homogentisate 1,2-dioxygenase missense variants in alkaptonuria." Eur J Pharmacol. 2025 Aug 8:178048. PMID: 40784658

9. Maria Petrosino, Karim Zuhra, et al. "Givinostat rescues folding of cystathionine beta-synthase and ameliorates murine homocystinuria." Biochem Pharmacol. 2025 Sep:239:117079. PMID: 40571220

10. Annika Ullrich, Johannes Schneider, et al. "Discovery of a functionally selective serotonin receptor (5-HT." Sci Adv.2025 Jun 20;11(25):eadv9267. PMID: 40531992

11. Yan Guo, Yong Zhang, et al. "Caffeic acid phenethyl ester protects." Elife. 2025 Jun 11:13:RP101757. PMID: 40497553

12. Jingheng Wang, Stanley Nithianantham, et al. "Decoding the selective chemical modulation of CYP3A4." Nat Commun. 2025 Apr 10;16(1):3423. PMID: 40210880

13. Minda Liu, Tianqi Fang, et al. "Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption." Bioorg Chem. 2025 Jun 1:159:108421. PMID: 40179579

14. Jaewon Song, Li Zhang, et al. "Norovirus co-opts NINJ1 for selective protein secretion." Sci Adv. 2025 Feb 28;11(9):eadu7985. PMID: 40020060

15. Wei Yang, Ying Xu, et al. "Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect." J Adv Res.2025 Feb12:S2090-1232(25)00111-0. PMID: 39952321

16. Ming Wei. "Identification of Novel Paclitaxel Sensitizers for Glioblastoma Therapy through High-Throughput Screening." International Journal of Frontiers in Medicine. ISSN 2706-6819 Vol.7, Issue 4: 74-84

17. Chenyu Yao, Peter Hart, et al. "Abstract 2138 Regulation of olaparib resistance in ovarian cancer using serotonin receptor modulators." Drug discovery and pharmacology Volume 301, Issue 5, Supplement 109058May 2025

18. Nikolina Radulovich;Pamela P. Soberanis, Molly Udaskin, et al. "Advancing precision cancer medicine with patient-derived organoids: an endometrial cancer case study." Cancer Res (2025) 85 (8_Supplement_1): 3997

19. Seigo Terawaki, Filipp Vasilev, et al. "Triclabendazole suppresses cellular glycosaminoglycan levels – a potential therapeutic agent for mucopolysaccharidoses and related diseases." Cell Symposia Volume 28, Issue 8113118 August 15, 2025

20. Meehee Park, Seungju Cho, et al. "Therapeutic potential of sulfasalazine for sarcopenia: Insights from mouse models and clinical data." Experimental Gerontology Available online 1 September 2025, 112883

21. Yan Guo, Boyuan Liu, et al. "2′-O-Galloylhyperin Prevents Tissue Remodeling in Thyroid Eye Disease: Prospects as a Thyrotropin Receptor Antagonist." The Journal of Clinical Endocrinology &amp;amp;amp;amp; Metabolism 02 December 2024. PMID: 39673421

22. Fraser Hughes, Alex Cookson, et al. "HTS Library Plate Rejuvenation Using a DMSO-Rich Atmosphere." SLAS Technol. 2024 Oct 11:100204. PMID: 39396728

23. Sunniva Sigurdardóttir, Suélen Fernandes Silva, et al. "An automated positive selection screen in yeast provides support for boron-containing compounds as inhibitors of SARS-CoV-2 main protease." Microbiol Spectr. 2024 Aug 20:e0124924. PMID: 39162260

24. Haiyan Dong, Chuangyu Wen, et al. "Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I." J Transl Med. 2024 Aug 14;22(1):769. PMID: 39143573

25. Chiaki T. Ishida, Casie S. Kubota, et al. "A High-Throughput Screening Platform Identifies FDA-Approved Drugs That Inhibit SREBP Pathway Activation." ACS Chem Biol. 2024 Aug 16;19(8):1695-1704. PMID: 39106256

26. Ruoxi Wu, Susmita Khamrui, et al. "Characterization, Structure, and Inhibition of the Human Succinyl-CoA: glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1." ACS Chem Biol. 2024 Jul 19;19(7):1544-1553. PMID: 38915184

27. Canrong Li, Yuguo Yi, et al. "TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors." Cell Biosci. 2024 Jun 1;14(1):68. PMID: 38824577

28. Yubao Fan, Shanshan Huang, et al. "The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias." Cell Rep Med. 2024 May 21;5(5):101559. PMID: 38744275

29. Yuting Pan, Ying Xuan, et al. "Time-dependent proteomics and drug response in expanding cancer cells." Pharmacol Res. 2024 Jun:204:107208. PMID: 38729587

30. Xiaojuan Zhang, Quanbin Xu, et al. "Chandipura Viral Glycoprotein (CNV-G) Promotes Gectosome Generation and Enables Delivery of Intracellular Therapeutics." Mol Ther. 2024 May 3:S1525-0016(24)00298-3. PMID: 38702887

31. Xiaoyu Chen, Huilin Zhao, et al. "Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes." Int J Antimicrob Agents. 2024 May;63(5):107160. PMID: 38537721

32. Susmita Khamrui, Tetyana Dodatko, et al. "Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1." bioRxiv. 2024 Feb 7:2024.02.07.578422. PMID: 38370847

33. Lanqin Wu, et al. "Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL." Cell Death Dis. 2024 Feb 8;15(2):122. PMID: 38331847

34. Soo Young Lee, et al. "5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis." Nat Commun. 2024 Feb 3;15(1):1024. PMID: 38310093

35. Yan Guo, Hongtao Liu, et al. "Novel metallo‐β‐lactamases inhibitors restore the susceptibility of carbapenems to New Delhi metallo‐lactamase‐1 (NDM‐1)‐harbouring bacteria." Br J Pharmacol. 2024 Jan;181(1):54-69. PMID: 37539785

36. Xiaodan Zhu, Shasha He, et al. "Protective Effect and Mechanism of Autophagy in Endothelial Cell Injury Induced by Hyperoxia." Am J Perinatol. 2024 May;41(S 01):e2365-e2375. PMID: 37516120

37. Siyi He, Luis Delgadillo Silva, et al. "A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions." bioRxiv [Preprint]. 2023 Dec 15:2023.12.14.571727. PMID: 38168191

38. Haya Albanna, Alesia Gjoni, et al. "Activation of Adrenoceptor Alpha-2 (ADRA2A) Promotes Chemosensitization to Carboplatin in Ovarian Cancer Cell Lines." Curr Issues Mol Biol. 2023 Nov 28;45(12):9566-9578. PMID: 38132444

39. Somaya A Abdel-Rahman, Katarzyna Świderek, et al. "First-in-class Small Molecule Inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators." RSC Med Chem. 2023 Aug 1;14(9):1767-1777. PMID: 37731692

40. Jie Zheng, Junjie Yang, et al. "CIL-ExPMRM: An Ultrasensitive Chemical Isotope Labeling Assisted Pseudo-MRM Platform to Accelerate Exposomic Suspect Screening." Environ Sci Technol. 2023 Aug 1;57(30):10962-10973. PMID: 37469223

41. Somaya A Abdel-Rahman, Ashfaq Ur Rehman, et al. "Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)." ACS Med Chem Lett. 2023 Apr 11;14(5):629-635. PMID: 37197466

42. Wei Yang, Xiongfei Sun, et al. "TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia." Biomed Pharmacother. 2023 Jul:163:114759. PMID: 37105077

43. Jingjing Zhang, Yingpei Jiang, et al. "Development of FRET and Stress Granule Dual-Based System to Screen for Viral 3C Protease Inhibitors." Molecules. 2023 Mar 28;28(7):3020. PMID: 37049786

44. Fabrizio Fierro, Lior Peri, et al. "Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands." Cell Mol Life Sci. 2023 Apr 3;80(4):114. PMID: 37012410

45. Zhiyu Song, Chenglong Zhao, et al. "Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6." Future Med Chem. 2023 Feb;15(4):333-344. PMID: 36946221

46. Liuqing Chen, Meiting Chen, et al. "Ratiometric NAD+ Sensors Reveal Subcellular NAD+ Modulators." ACS Sens. 2023 Apr 28;8(4):1518-1528. PMID: 36931900

47. Jing Han, Shuiqing Hu, et al. "Discovery of podofilox as a potent cGAMP–STING signaling enhancer with antitumor activity." Cancer Immunol Res. 2023 May 3;11(5):583-599. PMID: 36921097

48. Beatrice Alexander-Howden, Li Zhang, et al. "A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay." Sci Rep. 2023 Mar 8;13(1):3868. PMID: 36890145

49. Min Zheng, Cheng Yu, et al. "ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells.." Research Square. 10 Aug, 2023

50. Annika Ullrich, Johannes Schneider, et al. "Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain." bioRxiv. September 14, 2023

51. De-Ping Wang, Fang-Ying Jiang, et al. "Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors." Genes Dis. 2022 Jul 31;10(2):389-392. PMID: 37223502

52. Eirini D Tseligka, Stéphanie Conzelmann, et al. "Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries." JHEP Rep.2022 Dec 17;5(3):100652. PMID: 36704052

53. Dandan Jiang, Peizhi Ma. "Canagliflozin, characterized as a HDAC6 inhibitor, inhibits gastric cancer metastasis." Front Oncol. 2022 Nov 15;12:1057455. PMID: 36457493

54. Elizabeth R Sharlow, Danielle C Llaneza, et al. "High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons." SLAS Discov. 2022 Oct 21;S2472-5552(22)13703-2. PMID: 36273809

55. Xianglian Zhou, Yuting Pan, et al. "Tideglusib Inhibits Pif1 Helicase of Bacteroides sp. via an Irreversible and Cys-380-Dependent Mechanism." ACS Omega. 2022 Aug 25;7(35):31289-31298. PMID: 36092604

56. Jhin Jieh Lim, Lissa Hooi, et al. "Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors." J Exp Clin Cancer Res. 2022 Aug 15;41(1):249. PMID: 35971164

57. Youjie Yin, Peng Ma, et al. "The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila." Cell Death Dis. 2022 Aug 6;13(8):688. PMID: 35933423

58. Babak Andi, Desigan Kumaran, et al. "Hepatitis C virus NS3/4A inhibitors and other drug‑like compounds as covalent binders of SARS‑CoV‑2 main protease." Sci Rep. 2022 Jul 16;12(1):12197. PMID: 35842458

59. Can Cui, Yuting Pan, et al. "Eltrombopag binds SDC4 directly and enhances MAPK signaling and macropinocytosis in cancer cells." American Journal of Cancer Research, 15 Jun 2022, 12(6):2697-2710. PMID: 35812066

60. David Pladevall-Morera, María Castejón-Griñán, et al. "ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors." Cancers (Basel) 2022 Mar 31;14(7):1790. PMID: 35406561

61. Jian Guo, Sam Shen, et al. "JPA: Joint Metabolic Feature Extraction Increases the Depth of Chemical Coverage for LC-MS-Based Metabolomics and Exposomics." Metabolites. 2022 Feb 26;12(3):212. PMID: 35323655

62. Yubao Fan, Shanshan Huang, et al. "The adipose-neural axis is critically involved in cardiac arrhythmias." bioRxiv. June 13, 2022

63. Shiu-Wan Chan, Talha Shafi, et al. "Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step." Viruses.2021 Nov 19;13(11):2306. PMID: 34835112

64. Narmeen S Rashid, Nicole S Hairr, et al. "Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer." Transl Oncol.2021 Dec;14(12):101235. PMID: 34628286

65. Yunxia Xu, Ke Chen, et al. "Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease." Int J Biol Macromol. 2021 Oct 1:188:137-146. PMID: 34364941

66. Jing Nan, Shaoran Zhang, et al. "Discovery of Novel GMPS Inhibitors of Candidatus Liberibacter Asiaticus by Structure Based Design and Enzyme Kinetic." Biology (Basel). 2021 Jun 28;10(7):594. PMID: 34203217

67. Yan Ling Ng, Cyrill Kafi Salim, et al. "Drug repurposing for COVID-19: Approaches, challenges and promising candidates." Pharmacol Ther.2021 Dec;228:107930. PMID: 34174275

68. Xianglian Zhou, Yuting Pan, et al. "Tanshinones induce tumor cell apoptosis via directly targeting FHIT." Sci Rep. 2021 Jun 9;11(1):12217. PMID: 34108553

69. Alon Ben David, Eran Diamant, et al. "Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries." Molecules. 2021 May 27;26(11):3213. PMID: 34072087

70. James M. Havrilla, Cong Liu, et al. "PhenCards: a data resource linking human phenotype information to biomedical knowledge." Genome Med. 2021 May 25;13(1):91. PMID: 34034817

71. Peizhi Ma, Gang Jia, et al. "Monobenzone, a Novel and Potent KDM1A Inhibitor, Suppresses Migration of Gastric Cancer Cells." Front Pharmacol. 2021 Apr 15;12:640949. PMID: 33935733

72. Lesley-Anne Pearson, Charlotte J Green, et al. "Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry." SLAS Discov.2021 Jul;26(6):749-756. PMID: 33724070

73. Adam Pickard, Ben C Calverley, et al. "Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells." bioRxiv. 2021 Mar 10;2021.01.31.428851. PMID: 33564760

74. Gur D, Chitlaru T, Mamroud E, et al. "Screening of an FDA-Approved Library for Novel Drugs against Y. pestis." Antibiotics (Basel). 2021 Jan 3;10(1):40. PMID: 33401634

75. Moore JA, Meakin M, et al. "Effects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin." J Glob Antimicrob Resist. 2020;S2213-7165(20)30078-3. PMID: 32247076

76. Turner TH, Alzubi MA, et al. "Identification of synergistic drug combinations using breast cancer patient-derived xenografts." Sci Rep. 2020 Jan 30;10(1):1493. PMID: 32001757

77. Yang JJ, Han Y, et al. "Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction." Anal Chim Acta. 2020;1100:88–96. PMID: 31987156

摩尔浓度计算器

质量

= 浓度

x 体积

x 分子量

*在配置溶液时，请务必参考产品标签上、MSDS / COA（可在Apexbio的产品页面获得）批次特异的分子量使用本工具。

相关产品

L1021 DiscoveryProbe™ FDA-approved Drug Library

L1052 DiscoveryProbe™ Clinical & FDA approved Drug Library

L1021M DiscoveryProbe™ FDA-approved Drug Library Mini

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