Juvenile Hormone III
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg(solution) | 请咨询 | 请咨询 | |
| 5mg(solution) | 请咨询 | 请咨询 | |
| 10mg(solution) | 请咨询 | 请咨询 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Juvenile hormone III is an acyclic sesquiterpenoid that regulates diverse processes in insects, including adult transition of larvae and oogenesis in adult females[1,2]. It activates the juvenile hormone receptor, known as methoprene-tolerant, with a Kd value of 2.9 nM.2 Juvenile hormone III can be synthesized from farnesoic acid by two alternative pathways, one through methyl farnesoate and the other through juvenile hormone acid III[3,4].
References：
[1]. Tillman J A, Seybold S J, Jurenka R A, et al. Insect pheromones--an overview of biosynthesis and endocrine regulation. Insect Biochemistry and Molecular Biology, 1999, 29(6): 481-514.
[2]. Charles J P, Iwema T, Epa V C, et al. Ligand-binding properties of a juvenile hormone receptor, methoprene-tolerant. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(52): 21128-21133.
[3]. Defelipe L A, Dolghih E, Roitberg A E, et al. Juvenile hormone synthesis: "Esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase. Insect Biochemistry and Molecular Biology, 2011, 41(4): 228-235.
[4]. Navare A T, Mayoral J G, Nouzova M, et al. Rapid direct analysis in real time (DART) mass spectrometric detection of juvenile hormone III and its terpene precursors. Analytical and Bioanalytical Chemistry, 2010, 398(7-8): 3005-3013.
产品性质
| 物理外观 | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| CAS号 | 24198-95-6 |
| 分子式 | C16H26O3 |
| 分子量 | 266.38 |
| 化学名称 | (2E,6E)-methyl 9-(3,3-dimethyloxiran-2-yl)-3,7-dimethylnona-2,6-dienoate |
| 溶解度 | ≤12mg/ml in ethanol;10mg/ml in DMSO;14mg/ml in dimethyl formamide |
| SMILES | COC(/C=C(C)/CC/C=C(CCC1OC1(C)C)\C)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | (Rac)-幼年激素 III 是一种天然化合物；可从法尼苏酸中分离出来；是分布最广的幼年激素同源物。 |
质量控制
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Zhi-Xian Gong, Fu-Ping Cheng, et al. "The Juvenile-Hormone-Responsive Factor AmKr-h1 Regulates Caste Differentiation in Honey Bees." Biomolecules. 2023 Nov 17;13(11):1657. PMID: 38002339
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