2-Hydroxypropyl-β-cyclodextrin
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1g | ￥454.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide containing 7 glucopyranose units, with an average of one hydroxypropyl group per unit. The circular arrangement of the glucose units forms a torus-shaped ring configuration, and CH2 groups and ether linkages of the molecule face the hollow interior of the configuration, which leads to a nonpolar cavity and a polar exterior. When a compound with appropriate geometry and 2-hydroxypropyl-β-cyclodextrin are in the same solution, the nonpolar aromatic parts of that compound tend to interact with the nonpolar interior of the 2-hydroxypropyl-β-cyclodextrin molecule. This complexation isolates the aromatic parts of that compound from the water, thereby increasing its aqueous solubility. 2-Hydroxypropyl-β-cyclodextrin has been widely used in improving the aqueous solubility of a variety of compounds, especially those containing a phenyl group, a group encompassing many drugs.
References:
1. Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. International Research Journal of Pharmacy, 2012, 3(1): 52-56.
2. Shewale BD, Sapkal NP, Raut NA, et al. Effect of hydroxylpropyl-β-cyclodextrin on solubility of carvedilol. Indian Journal of Pharmaceutical Sciences, 2008, 70(2): 255-257.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 128446-35-5 |
| 分子式 | C63H112O42 |
| 分子量 | 1541.55 |
| 小分子别名 | HP-β-CD |
| 溶解度 | ≥24.9 mg/mL in EtOH; ≥42 mg/mL in DMSO; ≥47 mg/mL in H2O |
| SMILES | O[C@@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@H](O[C@@H]4[C@@H](O)[C@H](O)[C@H](O[C@@H]5[C@@H](O)[C@H](O)[C@H](O[C@@H]6[C@@H](O)[C@H](O)[C@H](O[C@@H]7[C@@H](O)[C@H](O)[C@H]8O[C@H]7COCC(O)C)O[C@H]6COCC(O)C)O[C@H]5COCC(C)O)O[C@H]4 |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | HP-β-CD （HP-β-CD）是一种广泛使用的给药载体，可提高药物的稳定性和生物利用度。 |
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