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JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

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生化试剂

  1. 产品编号 产品名称 信息
  2. A3012 Ruxolitinib (INCB018424) Top Seller JAK抑制剂
  3. B1130 GLPG0634 JAK1抑制剂
  4. A4517 ZM 449829 JAK3抑制剂
  5. A4513 Lestaurtinib JAK2/FLT3/TrkA抑制剂
  6. A4152 BMS-911543 JAK2抑制剂
  7. A4151 ZM 39923 HCl 有效的JAK3选择性抑制剂
  8. A4150 WHI-P154 JAK3抑制剂
  9. A4148 NVP-BSK805 2HCl JAK2抑制剂
  10. A4137 AZD1480 新型的ATP竞争性JAK2抑制剂
  11. A4135 Tofacitinib (CP-690550) Citrate Top Seller JAK抑制剂
  12. B6005 Peficitinb (ASP015K, JNJ-54781532) JAK抑制剂
  13. B5929 Decernotinib(VX-509) JAK3抑制剂
  14. B8023 Cerdulatinib Syk/JAK抑制剂
  15. A4514 NSC 33994 选择性JAK2抑制剂
  16. A4147 LY2784544 JAK2抑制剂
  17. A4136 TG101348 (SAR302503) Top Seller JAK-2抑制剂
  18. A3222 Baricitinib phosphate JAK1/JAK2抑制剂
  19. A3514 JAK2 Inhibitor V, Z3 Jak2酪氨酸激酶抑制剂
  20. A4140 WP1066 Top Seller 细胞通透的JAK2/STAT3抑制剂。
  21. A4141 Baricitinib (LY3009104, INCB028050) 可口服的JAK1/JAK2抑制剂
  22. A4143 CYT387 Top Seller JAK-1/-2抑制剂
  23. A4144 AZ 960 JAKs(janus相关激酶)抑制剂
  24. A4145 TG101209 Top Seller JAK2/3抑制剂
  25. A3221 Bardoxolone methyl IKK抑制剂,强效的抗氧化炎性反应调节剂。
  26. A3339 CYT387 sulfate salt JAK1/JAK2抑制剂
  27. A4146 CEP-33779 具高度选择性的JAK2抑制剂。
  28. A3936 WHI-P97 Janus激酶(JAK)-3抑制剂
  29. A3741 Pyridone 6 Pan-JAK抑制剂
  30. A3781 Ruxolitinib phosphate JAK1/JAK2抑制剂
  31. A3675 NVP-BSK805 Top Seller ATP竞争性JAK2抑制剂
  32. A4149 S-Ruxolitinib (INCB018424) JAK1/2抑制剂
  33. A4138 Tofacitinib (CP-690550,Tasocitinib) Janus激酶抑制剂
  34. A3937 XL019 有效的JAK2选择性抑制剂
  35. A3794 SB1317 CDK\JAK及FLT抑制剂
  36. A4510 1,2,3,4,5,6-Hexabromocyclohexane JAK2酪氨酸激酶抑制剂
  37. A4511 Cercosporamide Mnk2和JAK3抑制剂
  38. A3515 JANEX-1 JAK3 抑制剂
  39. A4512 Cucurbitacin I STAT3/JAK2信号转导抑制剂
  40. A4515 SD 1008 JAK2/STAT3信号通路抑制剂,细胞凋亡诱导剂
  41. A4516 TCS 21311 JAK3抑制剂