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iMAC2

现货
Catalog No.
A4464
MAC抑制剂
组合的产品项目
规格价格库存 数量
10mg
¥ 2,590.00
Ship with 10-15 days
50mg
¥ 10,910.00
Ship with 10-15 days

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Background

iMAC2 is the inhibitor of mitochondrial apoptosis-induced channel (MAC) with the IC50 value of 28 nM[1]. MAC is a putative cytochrome c release channel involved in the intrinsic apoptotic pathway. MAC has been associated with oligomeric, not monomeric, Bax[2]. By blocking MAC and suppressing cytochrome c release, iMAC2 suppressed the onset of apoptotic markers [1].

In vitro: In cultured apoptotic FL5.12 cells, pre-treatment with iMAC2 resulted in a normal volume and residual Annexin V/PI staining. iMAC2 reduced apoptosis by more than 50%. Pre-treatment with iMAC2 induced a significant protection at low micromolar levels (IC50 = 2.5 μM). Pre-incubation with iMAC2 and iMAC3 essentially eliminated the release of cytochrome c (P < 0.0001) while nanomolar levels of iMAC2 completely blocked the current flow through MAC. iMAC2 inhibited release of cytochrome c by Bid-induced Bax activation with the IC50 values of 0.68 μM [1].

References:
[1] Peixoto PM1, Ryu SY, Bombrun A, Antonsson B, Kinnally KW.  MAC inhibitors suppress mitochondrial apoptosis.Biochem J. 2009 Oct 12;423(3):381-7.
[2] Dejean L M, Martinez-Caballero S, Guo L, et al.  Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel[J]. Molecular biology of the cell, 2005, 16(5): 2424-2432.

Chemical Properties

Physical AppearanceWhite solid
StorageDesiccate at RT
M.Wt542.11
Cas No.335166-36-4
FormulaC19H20Br2FN3.2HCl
SolubilityLimited solubility
Chemical Name3,6-dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole
SDFDownload SDF
Canonical SMILESFC(CN1CCNCC1)CN2C3=C(C=C(Br)C=C3)C4=C2C=CC(Br)=C4
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

iMAC2