Ubiquitination/ Proteasome
Ubiquitination is a process in targeting proteins for degradation by the proteasome. Ubiquitin (Ub) is a 76 amino acid polypeptide which can be covalently attached to various cellular proteins by the ubiquitination process. This ubiquitin-proteasome system plays a vital role in cell division, growth, differentiation, transcriptional regulation, apoptosis and immunity etc. Three main types of enzymes are involved in the process of ubiquitination. In the first step, activation of ubiquitin is carried out by ubiquitin-activating enzyme (E1) through an ATP-dependent reaction. In the second step, the activated ubiquitin is transferred from E1 to ubiquitin-conjugating enzyme (E2). In the final step, the ubiquitin protein ligase (E3) is required for labeling the ubiquitin to target substrate protein. An isopeptide bond is formed between the carboxyl terminus of ubiquitin and the ε-amino group of a lysine residue in the target protein.
Once the substrate protein is labeled, proteasome will bind to a polyubiquitin chain, allowing the degradation of the labeled protein. The polyubiquitinated target protein is then recognized and degraded by the 26S proteasome. Deubiquitinating enzymes (DUBs) reverse the process of ubiquitination by removing ubiquitin from its substrate protein. Dysregulation of the ubiquitin-proteasome system has been linked to cancer, diabetes, cardiovascular and neurodegenerative diseases etc.
- B4755 PI-1840Summary: 胰凝乳蛋白酶样(CT-L)抑制剂
- B5797 PRT 4165Summary: Bmi1/Ring1A介导的泛素化抑制剂
- B5567 SMER 3Summary: 酵母SCF家族E3泛素连接酶(SCFMet30)抑制剂
- B7745 SZL P1-41Summary: Skp2抑制剂
- B7727 NSC 624206Summary: 泛素活化酶(E1)抑制剂
- B7637 SMER 28Summary: 自噬的正调节剂
- B3516 DUBs-IN-3Summary: 有效的去泛素化酶抑制剂
- B3515 DUBs-IN-2Summary: 去泛素化酶抑制剂
- B1391 Divalproex Sodium中文名: 双丙戊酸钠Summary: 癫痫/偏头痛/双相障碍药物
- B1395 Sulfacetamide Sodium中文名: 磺胺醋酰钠Summary: 磺酰胺抗生素