TGF-β / Smad Signaling - Selective
The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
- B5946 EW-71971 CitationTarget: BMP and Other Activin ReceptorsSummary: TGF-β I型受体激酶抑制剂
- B5858 ITD 1Summary: TGFβ抑制剂
- B6803 Rottlerin1 Citation中文名: 揪毒素Target: PKC|Ca2 /calmodulin-dependent protein kinases (CaMKs)|PRAK|MAPKAP-K2Summary: PKC抑制剂
- B3688 ML347Target: BMP and Other Activin ReceptorsSummary: 有效的BMP受体选择性抑制剂
- B3686 DMH-1Target: BMP and Other Activin ReceptorsSummary: BMP ALK2受体抑制剂
- A8830 ZIP (SCRAMBLED)Summary: PKMζ抑制剂
- B3392 GSK269962ATarget: ROCK|RSK|MSKSummary: ROCK抑制剂
- B1294 SR-3677Target: ROCKSummary: Rho激酶(ROCK-II)抑制剂
- B1293 Y-276329 CitationTarget: ROCKSummary: ROCK选择性抑制剂
- B2286 K02288Target: ALKSummary: ALK抑制剂