Stem Cell
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- C3882 PyrintegrinSummary: 增强hESC的存活
- C3625 IWP-2-V2Summary: Wnt生成抑制剂
- C3254 IWP-3Summary: Wnt生成抑制剂
- B7803 MK-4101Summary: Hedgehog(Hh)信号通路抑制剂
- B6110 IMR-1Summary: Notch途径抑制剂
- B6108 IC261Summary: CK1抑制剂
- K1022 Mouse iPSC Chemical Reprogramming Cocktails KitSummary: 从体细胞到多能干细胞的化学重编程。
- K1021 Mouse iPSC Chemical Reprogramming Cocktails Kit plusSummary: 从体细胞到多能干细胞的化学重编程
- B6059 Wnt agonist 11 CitationSummary: Wnt信号通路激动剂
- A8719 ML 239Summary: 乳腺癌干细胞抑制剂