MMP - Selective
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
- B4686 TAPI-12 CitationTarget: MMPSummary: TACE/ADAM17抑制剂
- A4436 GI 254023X2 CitationTarget: ADAMsSummary: ADAM10金属蛋白酶抑制剂
- A4442 WAY 170523Target: MMPSummary: MMP-13抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂
- A4051 NSC 4050201 CitationTarget: MMPSummary: MT1-MMP抑制剂
- A4050 GM 60012 Citation中文名: 伊洛马司他Target: MMPSummary: 广谱MMP抑制剂
- A4049 Marimastat1 Citation中文名: 马立马司他Target: MMPSummary: MMPs抑制剂