MMP
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
- A4440 UK 356618Summary: MMP-3抑制剂
- A4436 GI 254023X2 CitationTarget: ADAMsSummary: ADAM10金属蛋白酶抑制剂
- A4442 WAY 170523Target: MMPSummary: MMP-13抑制剂
- A4441 UK 3701061 CitationSummary: 高选择性MMP-3/MMP-12抑制剂
- A4438 PD 166793Summary: MMP抑制剂
- A4435 CP 471474Summary: 广谱MMP抑制剂
- A4434 CL 82198 hydrochlorideSummary: MMP-13抑制剂
- A4433 ARP 1011 CitationSummary: MMP的强效选择性抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂
- A3334 CTS-1027Summary: 金属蛋白酶(MMPs)抑制剂