Cathepsin - Cathepsins
Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.
清除全部
- A2487 Odanacatib (MK-0822)中文名: 奥当卡替Target: CathepsinsSummary: 组织蛋白酶K抑制剂
- A8239 CA-074 Me7 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4424 SID 26681509Target: CathepsinsSummary: 人组织蛋白酶L抑制剂
- A4412 MDL 28170Target: Cathepsins|CalpainsSummary: Calpain和cathepsin B抑制剂
- A3284 Cathepsin S inhibitor1 CitationTarget: CathepsinsSummary: 抑制MHCII抗原呈递
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A2576 E-642 CitationTarget: Cathepsins|Calpains|PapainsSummary: 半胱氨酸蛋白酶(cysteine protease)抑制剂
- A8174 Cathepsin G Inhibitor ITarget: CathepsinsSummary: Cathepsin G抑制剂