Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3抑制剂
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: 广谱caspase抑制剂
- A1901 Q-VD-OPh53 CitationTarget: CaspasesSummary: Pan-caspase抑制剂。
- A4016 Apoptosis Activator 2中文名: 凋亡激活剂2Summary: 吲哚二酮caspase激活剂
- A8177 PAC-11 CitationTarget: CaspasesSummary: 半胱天冬酶-3酶原激活剂