FAAH
Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.
- B5714 SA 47Summary: FAAH抑制剂
- B5704 SA 57Summary: FAAH抑制剂
- B5562 TC-F 2Summary: FAAH抑制剂
- B7701 JZL 195Summary: 脂肪酸酰胺水解酶(FAAH)和单酰基甘油脂肪酶(MAGL)的双重抑制剂
- B7356 PF 750Summary: FAAH抑制剂
- A3571 LY2183240Summary: 大麻素吸收高度有效的抑制剂
- A4374 PF-38451 CitationTarget: FAAHSummary: FAAH抑制剂
- A4372 URB597Summary: FAAH的强效选择性抑制剂
- A4361 JNJ-1661010Summary: FAAH的强效选择性抑制剂