Dehydrogenase - Selective
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
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- A8721 CBR-58841 CitationTarget: 3-phosphoglycerate dehydrogenaseSummary: PHGDH抑制剂
- B4929 GSK 2837808ATarget: Lactate Dehydrogenases (LDH)Summary: 乳酸脱氢酶A(LDHA)抑制剂
- A8703 IsosafroleTarget: Lactate Dehydrogenases (LDH)Summary: stiripentol类似物,有效的LDH抑制剂。
- B5508 Alda 1Target: Aldehyde DehydrogenasesSummary: ALDH2激活剂
- A3146 AGI-6780Target: IDH2Summary: IDH2/R140Q突变抑制剂