Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- C5195 6-(4-Methoxyphenyl)-3-pyridazinamineSummary: GABAA受体拮抗剂
- C5065 GSK1016790ASummary: TRPV4激动剂
- C5039 Quinacrine (hydrochloride hydrate)中文名: 奎纳克林二盐酸盐二水合物Summary: 电压依赖性钠通道阻滞剂
- C5110 FluspirileneSummary: 激动剂激活的L型钙通道的有效非竞争性拮抗剂
- C5049 AZD 3965Summary: 单羧酸转运蛋白1(MCT1)的有效抑制剂
- C5045 ML-297Summary: 选择性Kir3.1/3.2(GIRK1/2)通道激活剂
- C4851 MethsuximideSummary: 抗惊厥药
- C5010 IAA-94中文名: R(+)-甲基吲唑酮Summary: 氯化物通道抑制剂
- C4778 VU590 (hydrochloride)Summary: KCNJ1抑制剂
- C4729 Bafilomycin C1中文名: 巴菲霉素C1Summary: 液泡H+-ATPases(V-ATPase)抑制剂