GPCR/G protein
All GPCRs share a common seven trans-membrane structure. GPCRs are associated with heterotrimeric G-proteins which are GTP-binding proteins made of alpha, beta, and gamma subunits. When a ligand binds to GPCR, it activates the attached G-protein, the GDP is replaced with GTP. The activated G-protein then dissociates into an alpha and a beta-gamma complex which activates downstream signaling pathways. These intracellular signaling pathways include cAMP/PKA, calcium/NFAT, phospholipase C, protein tyrosine kinases, MAP kinases, PI-3-kinase, nitric oxide/cGMP, Rho, and JAK/STAT.
GPCRs are one of the most important therapeutic targets for various diseases, over 30% of all modern medicinal drugs target this family. Aberrant GPCR functions are involved in pathological conditions such as neurological, immunological and hormonal disorders. A large number of GPCRs have been identified, but whose ligands are not known, are classified as orphan receptors.
- B4876 K-Ras(G12C) inhibitor 12Summary: K-Ras(G12C)别构抑制剂
- C7093 Choline bitartrate
- C7040 Triflupromazine hydrochloride中文名: 盐酸三氟丙嗪
- C6995 Mebhydrolin napadisylate中文名: 美海屈林萘二磺酸盐
- C6974 Trimethobenzamide hydrochloride中文名: 盐酸曲美苄胺,盐酸三甲氧苯酰胺
- C6885 Deoxycholic acid sodium salt
- C6736 Nicotinamide N-oxide中文名: N-氧代烟酰胺;烟酰胺-N-氧化物
- C6723 Theophylline-7-acetic acid中文名: 茶碱乙酸;茶碱-7-乙酸
- C6709 Anethole trithione中文名: 茴三硫;胆维他;茴香脑三硫酮
- C6694 Methacholine chloride中文名: 醋甲胆碱;乙酰甲基氯化胆碱;氯化醋甲胆碱;氯化乙酰基-B-甲基胆碱;氯醋甲胆碱;氯化乙酰甲胆碱