DNA Damage/DNA Repair - Selective
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B6007 AZD67381 CitationTarget: ATM/ATRSummary: ATR抑制剂
- B4896 BMH-21Target: RNA PolymerasesSummary: RNA聚合酶I抑制剂
- B4856 CAY10603Target: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B4794 Santacruzamate A (CAY10683)Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- B7587 Puromycin dihydrochloride中文名: 嘌呤霉素盐酸盐Summary: 氨酰tRNA类似物,用于表达pac基因的稳定细胞株的筛选
- B7336 Thiostrepton中文名: 硫链丝菌素Target: FoxM1Summary: 抑制细菌蛋白合成的抗生素
- B3589 5-BrdU中文名: 溴尿苷Summary: 胸腺嘧啶核苷类似物
- B1471 Adenine HCl中文名: 腺嘌呤盐酸盐Target: Adenine receptorsSummary: 腺苷受体激动剂
- B2295 Pirarubicin1 Citation中文名: 吡柔比星Target: TopoisomerasesSummary: 拓扑异构酶II抑制剂,蒽环类抗生素
- B1476 Raltitrexed中文名: 雷替曲塞Target: Thymidylate SynthaseSummary: 胸苷酸合酶抑制剂