Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
- A4542 Alexidine dihydrochlorideSummary: PTPMT1抑制剂;PLB抑制剂
- A4541 Sal 003Summary: 细胞磷酸酶复合体抑制剂
- A4540 Okadaic acid中文名: 大田软海绵酸Summary: 蛋白磷酸酶1抑制剂
- A4539 NFAT InhibitorSummary: NFAT抑制剂
- A4538 INCA-6Summary: Calcineurin-NFAT信号通路抑制剂
- A4537 Fumonisin B1中文名: 伏马菌素B1Summary: PP5/PP2Cα/PP2A/PP1γ2/PP2B抑制剂
- A4536 Fostriecin sodium saltTarget: PP1|PP2A|Topoisomerases|PP4Summary: 抗肿瘤抗生素
- A4535 DL-AP3Summary: 谷氨酸受体拮抗剂和HPSP抑制剂
- A4534 Ceramide中文名: C2 神经酰胺Summary: 蛋白磷酸酶和CAPP调节剂
- A4533 Calyculin A中文名: 花萼海绵诱癌素,花萼海绵体诱癌素ASummary: 蛋白磷酸酶抑制剂