Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
- B6784 NSC 95397Summary: Cdc25双特异性磷酸酶抑制剂
- B7009 TautomycetinSummary: 蛋白磷酸酶(PP)1抑制剂
- B6881 NSC 6632841 CitationSummary: Cdc25双特异性磷酸酶抑制剂
- B1178 Nafamostat hydrochloride中文名: 盐酸萘莫司他Summary: 合成的丝氨酸蛋白酶抑制剂
- B1177 Nafamostat中文名: 萘莫司他Summary: 广谱丝氨酸蛋白酶抑制剂,激肽释放酶抑制剂
- B3274 CCT007093Summary: PPM1D抑制剂
- A8223 CID 2011756Summary: PKD抑制剂
- A4545 TCS 401Summary: 选择性PTP1B抑制剂
- A4544 NSC 87877Target: PTPSummary: Shp2/Shp1 PTP抑制剂
- A4543 BVT 948Summary: PTPs抑制剂