JAK
Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
- A4512 Cucurbitacin I中文名: 葫芦素 ITarget: STAT|JAKSummary: STAT3/JAK2信号转导抑制剂
- A4511 Cercosporamide中文名: 尾孢素酰胺Target: JAK|MNKSummary: Mnk2和JAK3抑制剂
- A4510 1,2,3,4,5,6-Hexabromocyclohexane中文名: 六氯环己烷Summary: JAK2酪氨酸激酶抑制剂
- A3937 XL019Target: JAKSummary: 有效的JAK2选择性抑制剂
- A3936 WHI-P97Summary: Janus激酶(JAK)-3抑制剂
- A3794 SB1317Summary: CDK\JAK及FLT抑制剂
- A3781 Ruxolitinib phosphate中文名: 鲁索利替尼Summary: JAK1/JAK2抑制剂
- A3741 Pyridone 6中文名: 吡啶酮6Target: JAKSummary: Pan-JAK抑制剂
- A3675 NVP-BSK805Summary: ATP竞争性JAK2抑制剂
- A3515 JANEX-1Summary: JAK3 抑制剂