Histone Methyltransferase
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
- B6088 EPZ020411Summary: PRMT6抑制剂
- B6085 AMI5/Eosin Y disodium saltSummary: 蛋白甲基转移酶抑制剂/伊红,用于苏木精伊红染色(HE染色)
- B6082 EPZ031686Summary: SMYD3抑制剂
- B6081 BAY-598Summary: SMYD2抑制剂
- B6048 SGC707Summary: PRMT3抑制剂
- B5913 C7280948Summary: PRMT1抑制剂
- B4989 EPZ015666Target: Protein Arginine MethyltransferasesSummary: PRMT5抑制剂
- B4949 WDR5 0103Summary: WD repeat-containing protein 5 (WDR5) antagonist
- B4948 UNC 2400Summary: UNC1999的阴性对照
- B4947 A 366Summary: G9a/GLP组蛋白赖氨酸甲基转移酶抑制剂