HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
- B4655 BMS-345541(free base)Summary: 有效的IKK-1/IKK-2选择性抑制剂
- B4106 4SC-202Summary: I类HDAC抑制剂
- B3704 Nexturastat ATarget: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B1251 Valproic acid中文名: 丙戊酸Target: Histone Deacetylases (HDACs)Summary: HDAC1抑制剂
- B1141 Varenicline HydrochlorideSummary: α4β2烟碱受体激动剂
- A8806 TMP269Summary: HDAC4/5/7/9抑制剂
- A8803 RGFP9664 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC3抑制剂
- A9906 HDAC Set ISummary: 抑制HDAC
- A8547 Tubastatin A HCl1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6(组蛋白去乙酰化酶6)抑制剂
- A4500 TCS HDAC6 20b1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6的选择性抑制剂