Cell Cycle/Checkpoint - Cell Experiments
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8717 THZ21 CitationTarget: Cyclin-Dependent KinasesSummary: CDK7抑制剂
- B4787 SF1670Target: PTENSummary: PTEN抑制剂
- A8736 THZ531Target: Cyclin-Dependent KinasesSummary: CDK12 和CDK13共价抑制剂
- B5860 TAK960Target: PLKSummary: PLK1抑制剂
- B5857 SBE 13 HClTarget: PLKSummary: 不活跃Plk1的抑制剂
- B4897 CCG-1423Target: RhoSummary: RhoA抑制剂
- B4892 TAI-1Target: Hec1Summary: Hec1抑制剂
- B6935 Aminopurvalanol ATarget: Cyclin-Dependent KinasesSummary: 细胞周期蛋白依赖性激酶抑制剂
- B4736 THZ1 HydrochlorideTarget: Cyclin-Dependent KinasesSummary: CDK7抑制剂
- B4094 NMS-1286937Target: PLKSummary: PLK1抑制剂