Cell Cycle/Checkpoint
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- C4087 Mebendazole中文名: 甲苯达唑Summary: 抑制肠微管合成的广谱驱虫药
- C3687 CCG-1006021 CitationSummary: Rho通路抑制剂
- C3767 Iso-OlomoucineSummary: Cdk5抑制剂奥洛莫辛(olomoucine)的无活性立体异构体
- C3679 Cdk1/2 Inhibitor IIISummary: Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A抑制剂
- C3889 FerulenolSummary: 具有抗分枝杆菌活性,刺激微管蛋白聚合
- C3995 Cdk4/6 Inhibitor IVSummary: Cdk4/cyclin D1和Cdk6/cyclin D1抑制剂
- C3340 3MB-PP1Summary: polo样激酶1(Plk1)等位基因抑制剂,ATP竞争性
- C3357 RS-1Summary: RAD51激活剂
- C3014 KJ Pyr 9Summary: c-Myc抑制剂
- C3012 SB 218078Summary: 检查点激酶1(Chk1)抑制剂