p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- A4202 RITA (NSC 652287)Summary: Mdm2-p53和p53泛素化抑制剂
- A4203 Tenovin-1Target: Sir2-like Family Deacetylases (Sirtuins)|p53|p21Summary: SIRT2 抑制剂,p53激活剂
- A4204 JNJ-26854165 (Serdemetan)1 CitationTarget: p53|HDM2 ubiquitin ligaseSummary: P53激活剂,阻断Mdm2-p53相互作用。
- A4206 Pifithrin-α (PFTα)2 CitationTarget: p53Summary: p53抑制剂
- A4228 Nutlin-3Target: MDM2Summary: MDM2 拮抗剂
- A4208 NSC 319726Target: p53Summary: 突变型p53的活性剂
- A1094 tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]Summary: p53结合蛋白片段。
- A1083 p53 tumor suppressor fragmentSummary: 调节细胞周期