Bcl-2 Family
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
- A3218 BAM7Summary: BAX激活剂
- A3196 AT-101中文名: (R)-(-)-棉子酚Target: NS3/4a ProteasesSummary: BH3-类似物,棉酚对映异构体
- A4199 Sabutoclax2 CitationTarget: Bcl-2|Mcl-1|Bfl-1Summary: Pan-Bcl-2抑制剂
- A4200 Apogossypolone (ApoG2)2 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2的非肽类小分子抑制剂
- A4194 Obatoclax mesylate (GX15-070)1 Citation中文名: 奥巴克拉甲磺酸盐Target: Bcl-2Summary: 强效的BCL-2抑制剂
- A4234 TW-371 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2抑制剂,抑制Bcl-2、Bcl-XL和Mcl-1。
- A3007 ABT-263 (Navitoclax)15 CitationTarget: Bcl-2|Bcl-wSummary: Bcl-2家族抑制剂,可以抑制Bcl-2、 Bcl-xL和Bcl-w。
- A8193 ABT-73714 CitationSummary: Bcl-2抑制剂
- A8194 ABT-19914 Citation中文名: 维奈妥拉Target: Bcl-2Summary: 选择性的Bcl-2抑制剂
- N2135 Gossypol2 Citation中文名: 棉籽酚,棉酚Target: DehydrogenaseSummary: PAF抑制剂,抗生育和抗癌