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Zinc protoporphyrin IX

锌原卟啉
Catalog No.
B6431
血红素加氧酶抑制剂
组合的产品项目
规格价格库存 数量
10mg
¥ 1,355.00
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50mg
¥ 5,699.00
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A

背景

Zinc protoporphyrin IX(ZnPP) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1].

ZnPP treatment weakened the ROS scavenging activity by PG  in H2O2-treated cells.Furthermore, the beneficial effect of PG on H2O2-induced DNA damage is significantly reduced by ZnPP[1].

Reference:

[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs, 2019, 13: 17(4).

文献引用

1.Ariyanti AD, Zhang J, et al. "Salidroside-Pretreated Mesenchymal Stem Cells Enhance Diabetic Wound Healing by Promoting Paracrine Function and Survival of Mesenchymal Stem Cells Under Hyperglycemia." Stem Cells Transl Med. 2019 Jan 9. PMID:30624028
2.Miao-Miao Zhou, Wen-Yan Zhang, et al. "DAnti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 Cells." Phytomedicine. 2018 March 8.

化学属性

Physical AppearanceA solid
StorageStore at RT
M.Wt626.03
Cas No.15442-64-5
FormulaC34H32N4O4Zn
Solubilityinsoluble in H2O; insoluble in EtOH; ≥20 mg/mL in DMSO
Chemical Namezinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
SDFDownload SDF
Canonical SMILESOC(CCC1=C(C)/C([N-]/C1=C\2)=C/C(C(C)=C/3C=C)=NC3=C/C4=N/C(C(C=C)=C4C)=C\C5=C(C)C(CCC(O)=O)=C2[N-]5)=O.[Zn+2]
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化学结构

Zinc protoporphyrin IX

相关生物数据

Zinc protoporphyrin IX

相关生物数据

Zinc protoporphyrin IX