Zileuton sodium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Zileuton sodium是5-脂氧合酶的抑制剂,抑制白三烯(LTB4\LTC4\LTD4和LTE4)形成,其IC50值为0.5 μM[1].
在RBL-1细胞裂解物中,Zileuton sodium呈浓度依赖性地抑制5-脂氧合酶活性,其IC50值为0.5 μM.此外,Zileuton sodium有效抑制LTB形成,其IC50值为0.6 μM.在经A23187刺激的大鼠白细胞中,Zileuton sodium呈剂量依赖性地减少LTB4和5-HETE生成,相应IC50值为0.38 μM和0.31 μM.Zileuton sodium在约40倍更高的剂量下也能减少PGE2生成,其IC50值为16 μM[1].
参考文献：
[1] Carter GW1, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, Summers JB, Brooks DW. 5-lipoxygenase inhibitory activity of zileuton. J Pharmacol Exp Ther. 1991 Mar; 256(3):929-37.
| Storage | Store at -20°C |
| M.Wt | 258.27 |
| Cas No. | 118569-21-4 |
| Formula | C11H11N2NaO2S |
| Solubility | Soluble in DMSO |
| SDF | Download SDF |
| Canonical SMILES | CC(N([O-])C(O)=N)C1=CC2=CC=CC=C2S1.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
