ZD 7288
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ZD 7288是超极化激活环核苷酸门控(HCN)通道抑制剂[1]。
HCN通道在窦房结(SAN)中发现,允许Na+和K+通过。HCN电流存在于细胞膜超极化的神经元中,在神经性疼痛中具有重要作用[1]。
在Wistar大鼠来源的CA1锥体细胞中,ZD 7288以浓度依赖的方式抑制T型Ca2+通道电流[2]。在新生大鼠面部运动神经元中,ZD-7288(0.1-10 μM)以时间和电压依赖的方式抑制超极化激活的电流,IC50值为0.2 μM[3]。在CA1锥体细胞中,ZD 7288(1-1000 μM)抑制超极化激活的电流。然而,ZD 7288对CA3-CA1突触的长时程抑制(LTD)没有影响[4]。
在慢性内脏痛大鼠中,ZD 7288(50-100 nM)显著抑制腹部回缩反射(AWR)评分和肌电图(EMG)反应。ZD 7288还显著增加痛阈。这些结果表明,脊柱HCN通道可能在慢性内脏痛中起关键作用[1]。
在大鼠慢性内脏痛,ZD 7288(50-100纳米)显著抑制腹部收缩反射(AWR)评分和肌电图(EMG)的反应。此外,ZD 7288显著疼痛阈值升高。这些结果表明,脊柱HCN通道可能在慢性内脏痛[1]中起关键作用。
参考文献:
[1]. Chen Y, Lin C, Tang Y, et al. ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol, 2014, 20(8): 2091-2097.
[2]. Sánchez-Alonso JL, Halliwell JV, Colino A. ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells. Neurosci Lett, 2008, 439(3): 275-280.
[3]. Larkman PM, Kelly JS. Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288. Neuropharmacology, 2001, 40(8): 1058-1072.
[4]. Gasparini S, DiFrancesco D. Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons. Pflugers Arch, 1997, 435(1): 99-106.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 292.81 |
Cas No. | 133059-99-1 |
Formula | C15H21ClN4 |
Solubility | Soluble in DMSO |
Chemical Name | (E)-N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride |
SDF | Download SDF |
Canonical SMILES | CCN(C1=CC=CC=C1)C2=C/C(N(C)C(C)=N2)=N\C.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |