YM-155 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
YM-155 hydrochloride是一种新型的小分子抑制剂，是细胞凋亡（IAP）基因家族抑制剂的最小成员。它对生存素具有强效的抑制活性，但对其他IAP家族成员或B细胞淋巴瘤2（BCL-2）相关蛋白的表达水平影响很小。YM155也广泛抑制人类肿瘤细胞系的增殖，可诱导非小细胞肺癌（NSCLC）、黑色素瘤、膀胱癌、侵袭性非霍奇金淋巴瘤和异种移植乳腺癌模型中的肿瘤消退，减少肿瘤自发转移，显著延长由人三阴性乳腺癌（TNBC）细胞系建立的转移性肿瘤动物的存活时间。
参考文献：
1. Naoki Kaneko, Kentaro Yamanaka, Aya Kita, Kenji Tabata, Takafumi Akabane, and Masamichi Mori. Synergistic antitumor activities of sepantronium bromide (YM155), a surviving suppressant, in combination with microtubule-targeting agents in triple-negative breast cancer cells. Biol Pharm Bull 2013.
2.Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang and Jian Pan. Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells. BMC Cancer 2012, 12:619
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 398.84 |
| Cas No. | 355406-09-6 |
| Formula | C20H19ClN4O3 |
| Synonyms | YM155 hydrochloride;YM 155 hydrochloride |
| Solubility | ≥19.45 mg/mL in DMSO; ≥4.34 mg/mL in EtOH with gentle warming and ultrasonic; ≥48.1 mg/mL in H2O with ultrasonic |
| Chemical Name | 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;chloride |
| SDF | Download SDF |
| Canonical SMILES | CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Cl-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | YM-155 hydrochloride是生存素的有效小分子抑制剂，IC50值为0.54 nM。 | |||||
| 靶点 | survivin | |||||
| IC50 | 0.54 nM | |||||
化学结构
相关生物数据
相关生物数据
