Xylazine HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Xylazine HCl是α2肾上腺素受体的强效激动剂[1]。
研究表明，在体给药剂量为2.5 mg/kg和5 mg/kg以及体外浓度为5 mM时，Xylazine HCl刺激大鼠胸腺细胞增殖[2]。在镇痛实验中，在纳洛酮存在40和50分钟时，Xylazine显著延长镇痛作用。此外，Xylazine可以对小鼠输精管产生一定的抑制作用，IC50值为18 nM。Xylazine对[3H]-dihydromorphine表现出有效的特异性结合抑制，在阿片受体结合实验中，IC50值为8 μM[1]。
参考文献：
[1] S. BROWNING, D.LAWRENCE1, A.LIVINGSTON & B.MORRIS. Interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] Coli M1, Cupi V, Pavici L, Vucevi D, Varagi VM. Xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):557-62.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 256.79 |
| Cas No. | 23076-35-9 |
| Formula | C12H16N2S·HCl |
| Solubility | ≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O |
| Chemical Name | N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
