WZ811
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WZ811是一种小分子的CXC趋化因子受体4(CXCR4)拮抗剂[1].
WZ811由两个芳香胺基团合成.该物质首先可有效地抑制TN14003结合CXCR4,EC50值为0.3 nM.随后,WZ811可阻碍SDF-1的功能,并阻断CXCR4/SDF-1介导的信号途径.在cAMP试验中,WZ811显著减少150 ng/ml SDF-1对cAMP的效果.该物质也阻断了SDF-1诱导的基质胶侵袭,EC50值为5.2 nM.由于CXCR4参与多种感染\炎症和其他疾病的病理,WZ811可开发用于治疗各种CXCR4相关疾病.该物质被报道在细胞培养中具有微弱的抗HIV活性[1,2].
参考文献：
[1] Zhan W, Liang Z, Zhu A, et al. Discovery of small molecule CXCR4 antagonists. Journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] Choi W T, Duggineni S, Xu Y, et al. Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). Journal of medicinal chemistry, 2011, 55(3): 977-994.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 290.36 |
| Cas No. | 55778-02-4 |
| Formula | C18H18N4 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥15.02 mg/mL in DMSO |
| Chemical Name | N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine |
| SDF | Download SDF |
| Canonical SMILES | C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | WZ811是一种高效的CXCR4竞争性拮抗剂,EC50值为0.3 nM. | |||||
| 靶点 | CXCR4 | |||||
| IC50 | 0.3 nM(EC50) | |||||
质量控制和MSDS
- 批次:
化学结构
