WZ8040
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WZ8040是一种新型的、不可逆的突变体选择性EGFR激酶抑制剂，特异性地抑制EGFR T790M的磷酸化。
WZ8040抑制含有EGFRT790M的细胞系的生长，同时抑制非小细胞肺癌（NSCLC）细胞EGFR的磷酸化。WZ8040是通过化合物筛选得到的，与临床期抑制剂，如HKI-272相比，WZ8040对PC9GR细胞的IC50低300倍[1]。
参考文献：
[1] Zhou W1,Ercan D,Chen L,Yun CH,Li D,Capelletti M,Cortot AB,Chirieac L,Iacob RE,Padera R,Engen JR,Wong KK,Eck MJ,Gray NS,Jnne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature.2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 481.01 |
| Cas No. | 1214265-57-2 |
| Formula | C24H25ClN6OS |
| Solubility | ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | WZ8040 is an irreversible inhibitor of EGFR T790M with IC50 value of <10nM. | |||||
| Targets | EGFR T790M | |||||
| IC50 | <10nM | |||||
质量控制和MSDS
- 批次:
化学结构
