WS6
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WS6是一种小分子的β细胞增殖诱导剂[1].
β细胞是胰岛中的一种细胞类型,通过产生胰岛素,在调节葡萄糖稳态中扮演重要作用[1].
WS6是一种小分子的β细胞增殖诱导剂.在小鼠β细胞系R7T1中,WS6可诱导细胞增殖,EC50值为0.28 M.WS6在原代人类和啮齿类胰岛中极具活性.在原代大鼠和人类β细胞中,WS6可诱导大鼠β细胞增殖,EC50值为0.4 M,并可增加4%的大鼠β细胞和3%的人类β细胞增殖.在完整胰岛培养物中,WS6可显著诱导增殖[1].在培养的人类胰岛中,WS6可诱导β细胞增殖和α细胞增殖.但是WS6不影响β细胞特异的转录因子表达和胰岛素阳性β细胞的数量,表明WS6不影响β细胞分化和人类胰岛细胞活力[2].
在I型糖尿病(T1D)小鼠中,WS6可显著降低血糖,并可将β细胞增殖从3.8%提高到6.4%[1].
参考文献：
[1]. Shen W, Tremblay MS, Deshmukh VA, et al. Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc, 2013, 135(5): 1669-1672.
[2]. Boerner BP, George NM, Mir SU, et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J, 2015, 62(4): 379-386.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 568.59 |
| Cas No. | 1421227-53-3 |
| Formula | C29H31F3N6O3 |
| Solubility | insoluble in H2O; ≥11.52 mg/mL in EtOH; ≥15.95 mg/mL in DMSO |
| Chemical Name | N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
