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VLX600

 
Catalog No.
C4072
对休眠癌细胞具有选择性细胞毒性
组合的产品项目
规格价格库存 数量
5mg
¥ 600.00
Ship with 10-15 days
10mg
¥ 981.00
Ship with 10-15 days
25mg
¥ 2,072.00
Ship with 10-15 days

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A

背景

VLX600 is a compound that is preferentially active against quiescent cancer cells [1].

Abnormal vascularization of solid tumors lead to the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells, which display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy [1].

VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation and displays tumour growth inhibition in vivo. In HCT116 colon carcinoma multicellular spheroids (MCS), VLX600 resulted in the appearance of central necrotic areas, induced active caspase-3 and led to a strong decrease in clonogenicity of dispersed cells. VLX600 also induced the expression of genes associated with hypoxia, glycolysis and p53 signaling. In HCT116 cells, VLX600 induces an autophagic response [1].

In NMRI nu/nu mice mice, VLX600 was rapidly distributed and finally eliminated with a half-life of 4-5 h. In mice bearing HCT116 and HT29 colon cancer xenografts, VLX600 exhibited antitumour activity and induced the formation of autolysosomes [1].

Reference:
Zhang X, Frykns M, Hernlund E, et al.  Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt317.4
Cas No.327031-55-0
FormulaC17H15N7
Solubility≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name1-(2-pyridinyl)-ethanone, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone
SDFDownload SDF
Canonical SMILESC/C(C1=NC=CC=C1)=N/NC2=NC3=C(C(C=CC=C4C)=C4N3)N=N2
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

VLX600