Vinpocetine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Vinpocetine是一种环GMP磷酸二酯酶(PDE)选择性抑制剂,Ki值为14±2 μM[1].
已报道,Vinpocetine对Ca2+ PDE具有选择性和非竞争性抑制作用, 以此调节平滑肌环GMP水平.除此之外,vinpocetine显示出对大鼠主动脉胞浆中三种可溶性PDE活性的抑制作用,对Ca2+ PDE(+)CaM\cGMP PDE和cAMP PDE 的Ki值分别为14±2 μM\>1000 μM和>1000 μM.除此之外,在内皮完整的大鼠主动脉中,vinpocetine对5-HT诱导的收缩显示出强的抑制作用,EC50值为1 μM[1].
参考文献:
[1] Souness JE1, Brazdil R, Diocee BK, Jordan R. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br J Pharmacol. 1989 Nov;98(3):725-34.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 350.45 |
Cas No. | 42971-09-5 |
Formula | C22H26N2O2 |
Solubility | ≥2.59 mg/mL in H2O with gentle warming and ultrasonic; ≥2.99 mg/mL in EtOH with ultrasonic; ≥5.83 mg/mL in DMSO |
Chemical Name | (41S,13aS)-ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate |
SDF | Download SDF |
Canonical SMILES | O=C(C(N1C2=C(C3=CC=CC=C13)CC4)=C[C@@]5(CC)[C@H]2N4CCC5)OCC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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