Vidofludimus
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Vidofludimus (4SC-101, SC12267) 是一种新型的二氢乳清酸脱氢酶(DHODH)小分子抑制剂,对人类DHODH的IC50值为134 nmol/L [1].
在体外酶实验中,Vidofludimus (4SC-101, SC12267)以剂量依赖的方式抑制DHODH,对人类DHODH\大鼠DHODH\小鼠DHODH和人类PBMC的IC50值分别为0.134 μmol/L, 1.29 μmol/L, 10.6 μmol/L和12.9 μmol/L[1].Vidofludimus对植物血凝素诱导的淋巴细胞增殖有抑制作用,IC50值约为13 μmol/L.Vidofludimus浓度依赖性地抑制植物血凝素刺激的人外周血单核细胞系(PBMCs)分泌白细胞介素-17,IC50值为6 μmol/L [2].
参考文献：
[1] Kulkarni OP1, Sayyed SG, Kantner C, Ryu M, Schnurr M, Sárdy M, Leban J, Jankowsky R, Ammendola A, Doblhofer R, Anders HJ. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas) lpr mice. Am J Pathol. 2010 Jun;176(6):2840-7.
[2] Fitzpatrick LR1, Deml L, Hofmann C, Small JS, Groeppel M, Hamm S, Lemstra S, Leban J, Ammendola A. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 355.36 |
| Cas No. | 717824-30-1 |
| Formula | C20H18FNO4 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO |
| Chemical Name | 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC(C2=CC=CC(OC)=C2)=CC=C1NC(C3=C(C(O)=O)CCC3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
