Vatalanib (PTK787) 2HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Vatalanib, 又称 PTK787,是一种有效的血管内皮生长因子(VEGF) 酪氨酸激酶受体抑制剂，它抑制了血管内皮生长因子(VEGF)受体/KDR、VEGF 受体/Flt-1以及VEGF受体/Flk,其半数最大抑制浓度IC50值分别为0.037 μM, 0.077 μM 和0.27 μM[1]。
Vatalanib也抑制同属酪氨酸激酶受体家族的其它酪氨酸激酶，包括血小板源生长因子受体β酪氨酸激酶(PDGFR-β)、c-Kit和c-Fms，IC50值分别为0.58 μM、0.73 μM 和1.4 μM [1]。
研究发现，Vatalanib可能作为潜在的治疗方式，用于治疗包括实体瘤在内的与血管生成相关的疾病[1]。
参考文献：
[1] Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rsel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister G, Schirner M, Thierauch KH, Schneider MR, Drevs J, Martiny-Baron G, Totzke F. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60(8):2178-89.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 419.73 |
| Cas No. | 212141-51-0 |
| Formula | C20H15ClN4·2HCl |
| Solubility | ≥21 mg/mL in DMSO; ≥24.5 mg/mL in H2O; ≥3.41 mg/mL in EtOH with ultrasonic |
| Chemical Name | N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
