Varenicline Hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Varenicline Hydrochloride是α4β2烟碱受体的部分激动剂,用于戒烟[1].
据报道,Varenicline Hydrochloride有效抑制烟碱型乙酰胆碱受体结合,对大鼠纹状体α6β2和α4β2烟碱型乙酰胆碱受体的Ki值分别为0.12 ± 0.02 nM和0.14 ± 0.01 nM,对猴纹状体α6β2和α4β2烟碱型乙酰胆碱受体的Ki值分别为0.13 ± 0.01 nM和0.19 ± 0.11 nM.此外,在大鼠纹状体中,Varenicline Hydrochloride比烟碱更能有效激活α6β2和α4β2烟碱型乙酰胆碱受体,相应EC50值为0.007 μM和0.086 μM[1].
参考文献:
[1] Bordia T1, Hrachova M, Chin M, McIntosh JM, Quik M. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. doi: 10.1124/jpet.112.194852. Epub 2012 May 1.
Storage | Store at -20°C |
M.Wt | 247.72 |
Cas No. | 230615-23-3 |
Formula | C13H14ClN3 |
Solubility | Soluble in DMSO |
Chemical Name | (6R)-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride |
SDF | Download SDF |
Canonical SMILES | Cl[H].[H]C1(C([H])([H])N([H])C2([H])[H])C([H])([H])[C@]2([H])C3=C([H])C4=NC([H])=C([H])N=C4C([H])=C13 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |